Project Examples
Examples of potential CMBB Biotech Bridge Hackathon team projects:
Example 1: Can we still beat AI-driven algorithms in predicting protein structures?
SWIP-10 and its human homolog MBLAC1 are linked to an increased risk of Alzheimer鈥檚 disease. Participants can develop a structural model of the protein SWIP-10 using a template-based modeling technique, in which the template search will be performed using the protein fold prediction protocol HHPred, based on Hidden Markov Model profiles (HMM) of amino acid sequences.
Example 2: Can you identify new molecular targets for old drugs?
RNA-targeting drugs represent novel strategies to address age-related diseases. Participants can develop algorithms to identify FDA-approved drugs potentially targeting RNA molecules.
Example 3: Can you spy the contaminant?
Per- and poly-fluoroalkyl substances (PFAS) exposure has numerous adverse effects, including cancer development, immune system suppression, reproductive toxicity, and neurotoxicity, with heightened risks observed in children and the elderly. Participants can identify methods that could detect PFAS real-time at a low cost.