glowing neurons

Lasm茅zas Laboratory at the Stiles-Nicholson Brain Institute

Our mission is to understand, prevent and halt neurodegeneration

The Lasm茅zas lab aims at unraveling fundamental mechanisms leading to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and other debilitating neurodegenerative diseases. By 2030, an estimated 70 million people will suffer from Alzheimer's related dementia worldwide and 9 million from Parkinson's disease. There is an urgent need to understand cellular death pathways and resistance mechanisms in order to devise new ways to prevent and/or treat neurodegenerative diseases. These disorders share a common mechanism where the dysfunction and death of brain cells is due to the toxicity of abnormally shaped and aggregated proteins which propagate from cell to cell. The Lasm茅zas group developed a new drug discovery platform tailored for this neurodegenerative mechanism, identified a novel target for Parkinson's disease, and discovered the role of alterations in the metabolism of the bioenergetic molecule NAD in neurodegeneration. Current studies build on these discoveries and aim at understanding how toxic amyloidogenic proteins accumulating during aging induce the demise of NAD metabolism in neurons and other cell types, identification of new therapeutic targets and development of new disease models as well as biomarkers to support translational efforts.

Lab Members
Corinne Lasmezas, DVM, Ph.D.
Corinne Lasmezas, DVM, Ph.D.
Principal Investigator
Bio
Corinne Lasm茅zas is an expert in neurodegenerative disease pathogenesis and therapeutics. She received her Ph.D. in Neurosciences from Sorbonne University, Paris, France, her Doctorate of Veterinary Medicine and her Diploma in Aeronautics and Space Medicine from the University of Toulouse, France. She led research labs at the Atomic Energy Commission in France and at the Scripps Research Institute in Jupiter, Florida, before joining the 大象传媒 Stiles-Nicholson Brain Institute as the inaugural Director of the David and Lynn Nicholson Center for Neurodegenerative Disease and Professor in the Department of Clinical Neurosciences at the Charles E. Schmidt College of Medicine. Lasm茅zas鈥 early work demonstrated that the new disease variant Creutzfeldt鈥揓akob disease (vCJD) was due to human infection by a toxic protein called a prion acquired from bovine spongiform encephalopathy (鈥渕ad cow disease鈥) and supported the worldwide implementation of life-saving public health protection measures. Her work contributed to understanding of prion biology, in particular how prions utilize the immune system to their advantage, travel in the body and are toxic to brain cells. Her current research spans several neurodegenerative diseases including Alzheimer's and other dementias, Parkinson's disease and amyotrophic lateral sclerosis. Research in the Lasm茅zas lab focuses on gaining in-depth understanding of cellular pathways leading to neurodegeneration, identification of new targets for intervention and development of novel therapeutic strategies.
Claire Rice, Ph.D.
Claire Rice, Ph.D., Postdoctoral Researcher
Bio
Claire Rice holds her bachelor鈥檚 degree in neuroscience and behavior, her master's degree in psychology and her Ph.D. in experimental psychology in neuroscience from 大象传媒. Her studies on ketamine-induced psychosis led to a new therapeutic approach involving selective modulation of small conductance calcium activated potassium channels. She conducted various studies on mechanisms of hippocampal-dependent memory and consolidation of trace fear memory. Claire provides key expertise in behavioral neuroscience to study interventions aimed at halting memory loss and other neurological symptoms of neurodegenerative diseases.
Oladiran Oladokun, M.S.
Oladiran Oladokun, M.S., Research Assistant
Bio
Oladiran Oladokun holds a bachelor's degree in biochemistry and a master's degree in biochemistry and molecular biology, with a focus on therapeutic applications of certain purified proteins, and a master's degree in biomedical engineering from 大象传媒, with a research focus on exploring diseases using Microelectromechanical systems (MEMS). Oladiran contributes to many aspects of the lab's research thanks to his expertise in protein biochemistry as well as in vitro and in vivo therapeutic studies.
Dhananjaya D., Ph.D.
Dhananjaya D., Ph.D., Postdoctoral Researcher
Bio
Dhananjaya D. is a neurobiologist with a Ph.D. from National Yang-Ming University and Academia Sinica, Taiwan. His doctoral research explored the pivotal role of the RNA-binding motif 4 (RBM4) protein in cell differentiation by regulating tissue-specific and developmentally controlled mRNA splice isoforms. With extensive expertise in genomic and RNA analyzes, neuronal cell culture, as well as early-stage drug discovery and pre-clinical transitions, Dr. Dhananjaya is exploring cellular pathways of misfolded protein-induced neurodegeneration and the impact on neuronal health of the lab鈥檚 neuroprotective approaches, in support of translational efforts.

Contact us

MAIN OFFICE

Florida Atlantic Stiles-Nicholson Brain Institute

Jupiter Campus

Room 201F, MC-22
5353 Parkside Drive, Jupiter, FL 33458
Phone: 561.799.8100

map of 大象传媒 Jupiter campus

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EDUCATION OFFICE

Florida Atlantic Stiles-Nicholson Brain Institute

Boca Raton Campus

Room 103A, SE-43
777 Glades Road, Boca Raton, FL 33431
Phone: 561.297.4989